Sumit pawar eth zurich

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Sumit pawar eth zurich	As INM proteins continue to gain prominence, we review these advancements and give an overview on the functional versatility of the INM proteome. When ER topology is altered, the long-range diffusional exchange of proteins in the ER network and targeting efficiency to the INM are diminished. Compared to the outer nuclear membrane and the contiguous peripheral ER, the inner nuclear membrane INM houses a unique set of transmembrane proteins that serve a staggering range of functions. Publication types Research Support, Non-U. Abstract Newly synthesized membrane proteins are targeted to the inner nuclear membrane INM by diffusion within the membrane system of the endoplasmic reticulum ER , translocation through nuclear pore complexes NPCs and retention on nuclear partners. Keywords: ER; GTPase; atlastin; biochemistry; cell biology; human; inner nuclear membrane; membrane protein; nuclear envelope.
1 btc to use 2010	The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publication types Research Support, Non-U. Highlighting the general importance of proper ER topology, we show that Atlastins also influence NPC biogenesis and timely exit of secretory cargo from the ER. Abstract The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic reticulum ER known as the nuclear envelope NE. When ER topology is altered, the long-range diffusional exchange of proteins in the ER network and targeting efficiency to the INM are diminished. Other INM proteins establish mechanical links between chromatin and the cytoskeleton, help NE remodeling, or contribute to the surveillance of NE integrity and homeostasis. Many of these functions reflect the exceptional position of INM proteins at the membrane-chromatin interface.
Dmtr crypto price prediction	Other INM proteins establish mechanical links between chromatin and the cytoskeleton, help NE remodeling, or contribute to the surveillance of NE integrity and homeostasis. Keywords: ER; GTPase; atlastin; biochemistry; cell biology; human; inner nuclear membrane; membrane protein; nuclear envelope. Using a visual in vitro assay we previously showed that efficient protein targeting to the INM depends on nucleotide hydrolysis. Newly synthesized membrane proteins are targeted to the inner nuclear membrane INM by diffusion within the membrane system of the endoplasmic reticulum ER , translocation through nuclear pore complexes NPCs and retention on nuclear partners. Recent research revealed that numerous INM proteins perform crucial roles in chromatin organization, regulation of gene expression, genome stability, and mediation of signaling pathways into the nucleus.
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Sumit pawar eth zurich	The funders had no role in study design, data collection and interpretation, or the decision to submit the work for publication. Publication types Research Support, Non-U. Abstract The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic reticulum ER known as the nuclear envelope NE. Using a visual in vitro assay we previously showed that efficient protein targeting to the INM depends on nucleotide hydrolysis. As INM proteins continue to gain prominence, we review these advancements and give an overview on the functional versatility of the INM proteome. The nuclear compartment is delimited by a specialized expanded sheet of the endoplasmic reticulum ER known as the nuclear envelope NE. Compared to the outer nuclear membrane and the contiguous peripheral ER, the inner nuclear membrane INM houses a unique set of transmembrane proteins that serve a staggering range of functions.
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Written by a previous postdoc in our lab, Sumit Pawar, and Ulrike Kutay, the review has been published in CSH perspectives in Biology and provides an. Newly synthesized membrane proteins are inserted into the endoplasmic reticulum (ER) from where they are constantly sorted to various cellular compartments. Experienced researcher skilled in High throughput screening, Drug discovery, Rare disease research, Cellular biochemistry, Scientific Writing, and Lecturing.